Royal Pains is a beloved medical comedy-drama that captivated audiences with its unique blend of humor, heart, and medical intrigue. If you’re a fan of this genre, you’re likely on the hunt for similar shows that can fill the void. Here are 16 TV shows like Royal Pains that you should definitely check out.

1. House

House follows the brilliant, but misanthropic Dr. Gregory House (Hugh Laurie) as he solves medical mysteries that baffle everyone else. With a team of young doctors, House uses unconventional methods to diagnose and treat patients.

2. Scrubs

Scrubs is a medical comedy-drama that centers on the lives of several employees working at Sacred Heart, a teaching hospital. Starring Zach Braff, Sarah Chalke, and Donald Faison, this show blends humor with poignant moments.

3. Grey’s Anatomy

Grey’s Anatomy is a long-running medical drama that delves into the personal and professional lives of surgical interns and their mentors. Ellen Pompeo stars as Meredith Grey, navigating the complexities of medical practice and relationships.

4. The Good Doctor

The Good Doctor features Freddie Highmore as Dr. Shaun Murphy, a young surgical resident with autism and savant syndrome. The series explores his exceptional medical skills and the challenges he faces due to his condition.

5. Private Practice

Private Practice is a spin-off of Grey’s Anatomy, focusing on Dr. Addison Montgomery (Kate Walsh) as she starts a new life at a private clinic in Los Angeles. The show dives into the personal and professional challenges faced by the clinic’s doctors.

6. Nurse Jackie

Nurse Jackie stars Edie Falco as Jackie Peyton, a nurse balancing the demands of her job with her own personal struggles, including addiction. The series offers a gritty, realistic look at the life of a healthcare professional.

7. Hart of Dixie

Hart of Dixie follows Dr. Zoe Hart (Rachel Bilson), a New York surgeon who relocates to a small town in Alabama to work at a general practice. The show blends medical drama with romantic and comedic elements.

8. The Resident

The Resident provides a behind-the-scenes look at the lives and duties of doctors at Chastain Park Memorial Hospital. Starring Matt Czuchry and Emily VanCamp, the series tackles ethical dilemmas and the complexities of the healthcare system.

9. Chicago Med

Chicago Med is part of the Chicago franchise and focuses on the emergency department at Gaffney Chicago Medical Center. The ensemble cast includes Nick Gehlfuss, Yaya DaCosta, and Torrey DeVitto, portraying the daily challenges faced by medical professionals.

10. Doc Martin

Doc Martin stars Martin Clunes as Dr. Martin Ellingham, a successful surgeon who becomes a general practitioner in a small Cornish village. The show combines medical cases with the quirky personalities of the village residents.

11. Saving Hope

Saving Hope centers on Dr. Alex Reid (Erica Durance) and her fiancé, Dr. Charlie Harris (Michael Shanks), who falls into a coma and becomes a spirit wandering the hospital. The show blends medical drama with supernatural elements.

12. New Amsterdam

New Amsterdam follows Dr. Max Goodwin (Ryan Eggold) as he becomes the medical director of one of the oldest public hospitals in the U.S. The series focuses on his efforts to reform the hospital and improve patient care.

13. ER

ER is a classic medical drama that ran for 15 seasons, depicting the lives of emergency room doctors and nurses at County General Hospital. The ensemble cast includes George Clooney, Julianna Margulies, and Noah Wyle.

14. A Young Doctor’s Notebook

A Young Doctor’s Notebook stars Jon Hamm and Daniel Radcliffe in a dark comedy based on the semi-autobiographical works of Mikhail Bulgakov. The series follows a young doctor in rural Russia during the Russian Revolution.

15. Call the Midwife

Call the Midwife is a period drama set in 1950s and 60s London, focusing on a group of nurse midwives working in the East End. The series, starring Jessica Raine and Helen George, explores social issues and medical challenges of the time.

16. The Night Shift

The Night Shift follows the late-night staff at San Antonio Memorial Hospital, dealing with a variety of medical emergencies. Starring Eoin Macken and Jill Flint, the series combines fast-paced medical drama with personal storylines.

Each of these shows offers a unique take on the medical drama genre, providing plenty of content to keep you entertained. Whether you’re looking for humor, romance, or intense medical cases, there’s something for everyone.